{"product_id":"abcam-ab290644","title":"Abcam, ab290644, Anti-Alpha-synuclein, isoform 98 and 126 antibody [EPR25117-81]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Alpha-synuclein antibody. Suitable for ICC\/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25117-81,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Alpha-synuclein, isoform 98 and 126.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlpha-synuclein isoform 98 and 126 also known as SNCA plays a mechanical role in neurons. This protein is an important part of the nerve cell cytoplasm distributed mainly in presynaptic terminals of the brain. With a molecular weight of about 14 kDa SNCA functions in both soluble and membrane-bound forms. Expression of alpha-synuclein occurs in the central nervous system but it is seen in some peripheral tissues too.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein contributes to the regulation of synaptic vesicle trafficking and neurotransmitter release. As part of a complex alpha-synuclein interacts with a variety of other synaptic proteins affecting vesicle mobility and ensuring efficient synaptic transmission. It influences neuronal plasticity and survival supporting nervous system function. Though still under investigation these functions indicate a regulatory role in maintaining neural communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nOne can see the involvement of alpha-synuclein in the dopamine and calcium signaling pathways. These pathways impact synaptic transmission with overlaps including proteins like LRRK2 and parkin. Alpha-synuclein's regulation of cellular transport processes connects these pathways impacting their overall function by modulating synaptic vesicle dynamics.\u003cbr\u003e\nAlpha-synuclein is linked to Parkinson's Disease and Lewy Body Dementia. These neurodegenerative disorders show abnormal accumulation of the protein. Interactions between SNCA and others such as tau protein and amyloid precursor protein lead to pathological changes. Understanding these interactions provides insight into how alpha-synuclein contributes to disease mechanisms making it an important focus for therapeutic research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850400190633,"sku":"ab290644","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab290644","provider":"Iright","version":"1.0","type":"link"}