{"product_id":"abcam-ab300129","title":"Abcam, ab300129, Anti-Cofilin 2 antibody [EPR24519-7] (BSA and Azide free)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Cofilin 2 antibody. Carrier free. Suitable for WB, IHC-P, Flow Cyt (Intra), IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24519-7,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCofilin 2 also referred to as CFL2 is an actin-binding protein that plays a significant role in actin dynamics by disassembling actin filaments. It has a molecular mass of approximately 19 kDa. This protein is expressed predominantly in muscle tissues including skeletal and cardiac muscle. Cofilin 2 is integral in the maintenance and reorganization of the actin cytoskeleton facilitating cellular movement and shape changes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCofilin 2 is involved in processes including muscle contraction and cytoskeletal organization. It participates in the depolymerization of actin filaments thereby accelerating filament turnover and recycling. It does not function in isolation but interacts with several proteins in the cytoskeleton forming a complex interplay that modulates actin filament dynamics. Its activity is regulated by phosphorylation with specific kinases and phosphatases modulating its function based on cellular signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nCofilin 2 is an important element of the actin reorganization pathway and is involved in the Rho family GTPase signaling pathway. It works closely with proteins like LIM kinase which phosphorylates cofilin and inhibits its activity and slingshot phosphatase which dephosphorylates and activates it. This regulation ensures proper actin filament dynamics which is essential for processes like cell division migration and muscle function.\u003cbr\u003e\nCofilin 2 mutations have been associated with nemaline myopathy a muscle disorder characterized by muscle weakness. This disorder often involves abnormalities in the neuromuscular junction where cofilin 2 interacts with actin and related proteins like tropomyosin affecting muscle contraction. Additionally altered cofilin 2 expression links to cardiac complications due to its role in cardiac muscle maintenance and actin filament dynamics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851630497961,"sku":"ab300129","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab300129","provider":"Iright","version":"1.0","type":"link"}