{"product_id":"abcam-ab300142","title":"Abcam, ab300142, Anti-TRPC3 antibody [EPR25056-56]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TRPC3 antibody. Suitable for IHC-P, WB and reacts with Transfected cell line - Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25056-56,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe TRPC3 protein also known as transient receptor potential cation channel subfamily C member 3 is a fundamental component of the plasma membrane and participates in forming a non-selective cation channel. With a molecular mass of approximately 97 kDa TRPC3 channels are widely expressed in the brain heart and vascular smooth muscle. These channels mediate calcium and to a less degree sodium influx when activated facilitating various cellular responses. Additionally TRPC3 channels can interact with other proteins within the same family shaping the channel's functional properties.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTransient receptor potential channels like TRPC3 play important roles in cellular calcium signaling with direct implications in neuronal cardiac and smooth muscle functions. TRPC3 proteins can assemble into heteromultimeric complexes with other TRPC family members often modulating their biophysical characteristics and responsiveness to stimuli. In neurons TRPC3 channels contribute to synaptic transmission and plasticity by influencing intracellular calcium levels. In smooth muscle cells TRPC3 activity influences contraction and relaxation processes affected by calcium flux regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nInositol triphosphate (IP3) and phospholipase C (PLC) pathways notably involve TRPC3 activity. TRPC3 cooperates with the IP3 receptor to mediate calcium release from the endoplasmic reticulum enhancing cellular calcium entry. This interaction ties TRPC3 functionally to the regulation of important physiological processes like cardiac hypertrophy and vascular tone. Additionally TRPC3's relationship with proteins such as calmodulin and STIM1 further illustrates its role in calcium signaling pathways.\u003cbr\u003e\nAltered TRPC3 activity relates to conditions such as cardiac hypertrophy and neurodegenerative diseases. The protein's dysregulation can result in disrupted calcium homeostasis contributing to excessive cardiac cell growth and potential heart failure. In the nervous system TRPC3 has links to Huntington's disease where its abnormal function associates with neuronal survival and synaptic alterations. The interaction of TRPC3 with proteins such as huntingtin in these pathological contexts highlights its participation in disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850353070249,"sku":"ab300142","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab300142","provider":"Iright","version":"1.0","type":"link"}