{"product_id":"abcam-ab300479","title":"Abcam, ab300479, Anti-SETD1B antibody [EPR25142-11]","description":"\u003cp\u003eSize: 10µL-TRIAL \/ 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SETD1B antibody. Suitable for Flow Cyt (Intra), ICC\/IF, IHC-P, WB and reacts with Mouse, Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25142-11,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSETD1B also known as KMT2G is a histone methyltransferase protein with a molecular mass of approximately 200 kDa. It functions mechanically by specifically methylating lysine 4 on histone H3 (H3K4) a critical action for chromatin modification. This methylation regulates gene transcription and the enzyme predominantly exerts its effects in the nucleus. SETD1B expresses across various tissues which suggests a broad regulatory role in different cellular environments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of SETD1B extends to functioning as part of the SET1\/MLL complex which is responsible for the mono- di- and tri-methylation of histone H3 at lysine 4 (H3K4). The complex plays a significant role in transcriptional regulation influencing gene activation and silencing across different cellular processes. SETD1B's activity modulates the expression of genes involved in the regulation of development differentiation and cellular proliferation impacting numerous biological outcomes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of SETD1B in gene expression regulation positions it notably in the Wnt signaling pathway. This pathway is important for controlling cell fate and proliferation. Furthermore SETD1B interacts with other proteins like β-catenin enhancing transcription of Wnt target genes. Additionally SETD1B takes part in the regulation of pathways involving chromatin remodeling associating closely with proteins such as ASH2L which affects histone methylation states.\u003cbr\u003e\nAlterations in SETD1B are linked to intellectual disability and autism spectrum disorders. Disruptions in the protein's methylation function can lead to improper gene expression patterns emphasizing its association with neurodevelopmental conditions. SETD1B also connects with the CBP protein in certain cancer pathways where abnormal histone modification can drive oncogenesis. These interactions highlight SETD1B's significance in maintaining regular cellular function and its potential impact when mutant or dysregulated.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850322956457,"sku":"ab300479","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab300479","provider":"Iright","version":"1.0","type":"link"}