{"product_id":"abcam-ab300489","title":"Abcam, ab300489, Anti-NSD3 antibody [EPR25189-8]","description":"\u003cp\u003eSize: 10µL-TRIAL \/ 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NSD3 antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra), IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25189-8,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, WB, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNSD3 also known as WHSC1L1 is a protein involved in gene expression regulation through its role as a histone methyltransferase. It has a molecular mass of approximately 170 kDa. This protein specifically modifies lysine residues on histone tails which influences chromatin structure and gene transcription. NSD3 is broadly expressed in various tissues but higher levels appear in actively dividing cells such as those found in the brain and reproductive organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNSD3 plays an important role in the regulation of chromatin state and is part of the larger SETD2 family of methyltransferases. It forms part of complexes that influence transcriptional activation and repression by altering chromatin accessibility. These complexes allow NSD3 to exert control over genes involved in cell proliferation and differentiation impacting cellular processes critical to development and tissue maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nNSD3 integrates into chromatin remodeling and gene expression pathways. It interacts with other methyltransferases and proteins like NSD1 and NSD2 to regulate transcriptional programs essential for cellular growth. It is part of pathways that modulate key processes such as the cell cycle and DNA damage response indicating its role in maintaining genomic stability and regulating cell fate decisions.\u003cbr\u003e\nNSD3 has implications in cancer development and progression. It is particularly linked to certain types of breast cancer where overexpression leads to uncontrolled cell growth. In these cases NSD3 influences oncogenic pathways and interacts with proteins such as BRD4 to drive tumorigenesis. Its dysregulation might also contribute to neurodevelopmental disorders by affecting proteins involved in neural development and connectivity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855875854505,"sku":"ab300489","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab300489","provider":"Iright","version":"1.0","type":"link"}