{"product_id":"abcam-ab300522","title":"Abcam, ab300522, Anti-KAT5 \/ Tip60 antibody [EPR23728-112] (BSA and Azide free)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal KAT5 \/ Tip60 antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra), IP and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23728-112,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKAT5 also known as Tip60 is a histone acetyltransferase with a molecular mass of approximately 60 kDa. This enzyme plays an important mechanical role in regulating chromatin dynamics by acetylating lysine residues on histone tails which affects gene expression. It is also involved in non-histone protein acetylation influencing various signaling pathways. KAT5 is expressed across many tissues with higher levels observed in the brain heart and testis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKAT5 acetylates histones and participates in the regulation of transcription DNA repair and cell cycle progression. It is a critical component of the NuA4 complex which includes other important proteins like EP400 and TRRAP. Through its acetylation activity KAT5 affects chromatin structure thereby influencing gene expression involved in growth control apoptosis and DNA repair mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nKAT5 is integrally involved in processes such as the DNA damage response and apoptosis. Within these pathways KAT5 interacts with proteins like p53 which plays a significant role in maintaining genomic stability. KAT5-mediated acetylation modulates p53's activation and its ability to engage in apoptotic pathways as well as the cell's response to DNA damage.\u003cbr\u003e\nKAT5 has links to neurodegenerative disorders and cancer. Its dysregulation may contribute to the development of Alzheimer's disease through altered acetylation of tau protein; abnormalities in tau acetylation are implicated in this disorder. Similarly in cancer interactions with proteins like MYC suggest KAT5's involvement in oncogenic pathways. Changes in KAT5 expression or activity have been observed in certain cancers highlighting its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851852173481,"sku":"ab300522","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab300522","provider":"Iright","version":"1.0","type":"link"}