{"product_id":"abcam-ab300665","title":"Abcam, ab300665, Anti-IMP5 antibody [1A1]","description":"\u003cp\u003eSize: 10µg-TRIAL \/ 20µg \/ 100µg \/ 1mg\u003cbr\u003e\nRat Recombinant Monoclonal IMP5 antibody. Suitable for WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:1A1,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIMP5 also known as Importin 5 is a protein that functions mechanically by facilitating the nuclear import of certain proteins and ribonucleoproteins. This nuclear transport process is critical for regulating gene expression and maintaining cellular homeostasis. The molecular mass of IMP5 is approximately 116 kDa. Expression of IMP5 occurs in various cell types with notably higher levels in rapidly dividing cells where active nuclear transport is essential for cell cycle progression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIMP5 plays a critical role in the nuclear-cytoplasmic transport system by forming a complex with other importins to shuttle cargo proteins across the nuclear envelope. This transport is necessary for the regulation of transcription factors and other proteins that impact cellular function. IMP5's involvement in the import complex highlights its importance in regulating components that influence cell growth and metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nIMP5 participates in the nuclear import pathway which is part of the broader cell signaling and regulation framework. It particularly interacts with Ran GTPase an important regulator of nucleocytoplasmic transport facilitating the import cycle of cargo complexes. Its action is also significant in the p53 signaling pathway where regulation of nuclear transport affects the activity and localization of p53 and associated proteins impacting cell cycle and apoptosis processes.\u003cbr\u003e\nIMP5 has connections with cancer and neurodegenerative diseases. Its elevated expression links to various cancers where dysregulated nuclear import can impact tumor suppressor functions. Specifically it relates to the misregulation of p53 a protein frequently mutated in cancer. In neurodegenerative disorders altered nuclear transport involving IMP5 may disturb neuronal function and survival. Dysfunction in these pathways reveals the importance of IMP5 in both maintaining normal cellular function and its implication in disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855413891241,"sku":"ab300665","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab300665","provider":"Iright","version":"1.0","type":"link"}