{"product_id":"abcam-ab302707","title":"Abcam, ab302707, Anti-MCT8 antibody [EPR26257-174] (BSA and Azide free)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MCT 8 antibody. Carrier free. Suitable for IP, Flow Cyt (Intra), ICC\/IF, IHC-Fr, IHC-P, WB and reacts with Rat, Mouse, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26257-174,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Mouse, Human,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), IHC-Fr, ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMCT 8 also known as monocarboxylate transporter 8 is a protein important for transporting thyroid hormones across cell membranes. This transporter has a mass of approximately 61 kDa. MCT 8 is widely expressed in various tissues including the brain liver and kidneys with a significant presence in neurons. This transporter plays an important mechanical role in hormone regulation by facilitating the cellular uptake and efflux of triiodothyronine (T3) and thyroxine (T4) critical components for proper cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMCT 8 serves a significant role in maintaining normal thyroid hormone levels within cells affecting development and metabolism. It does not act alone but operates as part of a cooperative network with other transporters and receptors to ensure precise hormonal balance. Its activity impacts processes like energy generation and usage as well as nervous system development. MCT 8's ability to mediate hormone access to target tissues highlights its importance in these biological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMCT 8 is intricately involved in the thyroid hormone signaling pathway. This pathway influences diverse metabolic and developmental outcomes. MCT 8 works closely with other proteins such as thyroid hormone receptor alpha (THRA) that also bind and respond to thyroid hormones. The synchronization between MCT 8 and these proteins ensures effective communication and function within the hormonal axis impacting metabolic regulation and growth.\u003cbr\u003e\nMCT 8 mutations connect strongly to Allan-Herndon-Dudley syndrome a rare neurodevelopmental disorder. This condition arises from disrupted thyroid hormone transport leading to developmental and cognitive deficiencies. Patients typically exhibit reduced T3 levels in the brain. In this context MCT 8's relationship with proteins like THRA reveals how perturbations in hormone transport can cascade into broader physiological abnormalities.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851273621673,"sku":"ab302707","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab302707","provider":"Iright","version":"1.0","type":"link"}