{"product_id":"abcam-ab302716","title":"Abcam, ab302716, Anti-Ryanodine receptor 2\/RYR-2 antibody [EPR26288-70]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-Ryanodine receptor 2\/RYR-2 antibody [EPR26288-70] (ab302716) is a rabbit monoclonal antibody detecting Ryanodine receptor 2\/RYR-2 in  Western Blot, IP, IHC-P, IHC-Fr . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26288-70,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-P, IP, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Ryanodine receptor 2\/RYR-2 antibody [EPR26288-70] (ab302716) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of Ryanodine receptor 2\/RYR-2?\u003cbr\u003e\nAnti-Ryanodine receptor 2\/RYR-2 [EPR26288-70] (ab302716) specifically detects a band for Ryanodine receptor 2\/RYR-2 (UniProt: Q92736) at a molecular weight of 565kDa.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR26288-70] also available for your convenience: ab302716, Carrier free -\u003cbr\u003e\nab302717\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ryanodine receptor 2 (RYR-2) also known as cardiac ryanodine receptor is an intracellular calcium release channel that plays an important role in cardiac muscle contraction. This large protein has a mass of about 564 kDa and is mainly expressed in cardiac muscle tissue. Mechanically RYR-2 regulates the release of calcium ions from the sarcoplasmic reticulum into the cytosol. This calcium release occurs through the calcium-induced calcium release mechanism which is important in excitation-contraction coupling in cardiac muscle cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRYR-2 enables the heart muscle cells to contract and relax by supplying calcium ions necessary for muscle contraction. It is part of a larger complex that includes proteins such as FK506-binding protein 12.6 (FKBP12.6) and calsequestrin which help regulate its function. Proper function of this complex is necessary for maintaining the rhythmic contraction and relaxation cycles of the heart. Any disruptions in this function can lead to irregular heartbeats.\u003cbr\u003e\nPathways\u003cbr\u003e\nRYR-2 is significant in cardiac calcium signaling pathways that involve calcium-induced calcium release. Through this pathway it works closely with L-type calcium channels like Cav1.2 which are responsible for the initial influx of calcium that activates RYR-2. This cooperation allows for the amplification of calcium signals needed for strong cardiac muscle contractions. Proper signaling in these pathways is necessary for maintenance of heart rhythm and contractile strength.\u003cbr\u003e\nRYR-2 mutations associate with several cardiac disorders including catecholaminergic polymorphic ventricular tachycardia (CPVT) and arrhythmogenic right ventricular dysplasia type 2 (ARVD2). These conditions involve irregular heartbeats often triggered by physical exercise or stress. The relationship between RYR-2 and these disorders connects through its dysfunction in calcium signaling regulation which impacts heart rhythm stability. The malfunctioning of RYR-2 also affects related proteins like FKBP12.6 contributing further to disrupted calcium homeostasis and arrhythmic events.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855834566825,"sku":"ab302716","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab302716","provider":"Iright","version":"1.0","type":"link"}