{"product_id":"abcam-ab302718","title":"Abcam, ab302718, Anti-AXL (phospho Y702) + MERTK (phospho Y753) + TYRO3 (phospho Y685) antibody [EPR26140-66]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Axl phospho Y702 antibody. Suitable for WB, IP, Dot and reacts with Human, Transfected cell lysate - Human, Synthetic peptide samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26140-66,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody cross-reacts with phosphorylated MERTK Y753 and TYRO3 Y685 based on dot blot data.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAxl MERTK and TYRO3 are receptor tyrosine kinases collectively known as TAM receptors. These proteins play important roles in cell signaling with Axl weighing around 98 kDa MERTK approximately 110 kDa and TYRO3 approximately 93 kDa. They are expressed in various tissues including the immune system the nervous system and reproductive organs. TAM receptors depend on ligands like Gas6 and Protein S to carry out their signaling mechanisms which are essential for their function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAxl MERTK and TYRO3 contribute to diverse cellular processes such as cell survival proliferation and phagocytosis. They form complexes with their ligands triggering downstream signaling pathways that regulate these vital processes. These receptors also maintain homeostasis in various systems by regulating the clearance of apoptotic cells and controlling immune response. Their signaling pathway often involves phosphorylation events that transmit signals from the extracellular environment into the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese receptors mainly participate in the PI3K\/AKT and MAPK pathways acting as key modulators in cell growth and immune response. TAM receptors interact with molecules like PI3K an important mediator in the AKT pathway facilitating cellular processes like metabolism growth and survival. Their interactions support critical feedback loops that balance cellular functions and immune system adaptability.\u003cbr\u003e\nDysregulation of Axl MERTK and TYRO3 associates with cancer and autoimmune diseases. Overexpression or underexpression of these receptors can lead to tumor progression or inadequate immune response respectively. In cancer overactivated Axl often partners with EGFR or MET leading to enhanced proliferation and metastasis of cancerous cells. In autoimmune disorders such as systemic lupus erythematosus MERTK dysregulation can result in improper clearance of apoptotic cells contributing to persistent inflammation and autoantibody production.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848558989481,"sku":"ab302718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab302718","provider":"Iright","version":"1.0","type":"link"}