{"product_id":"abcam-ab302776","title":"Abcam, ab302776, Anti-ASIC3 antibody [EPR26557-80]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ASIC3 antibody. Suitable for WB, IHC-P, IP, ICC\/IF and reacts with Mouse, Rat, Transfected cell line - Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26557-80,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WB, IP, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nASIC3 also known as Acid-Sensing Ion Channel 3 or DRASIC is a protein channel involved in detecting variations in pH. This protein has a molecular mass of approximately 56 kDa and falls within the ASIC family of proton-gated sodium channels. ASIC3 is widely expressed in peripheral sensory neurons particularly in dorsal root and trigeminal ganglia which are areas pivotal for detecting pain and mechanosensation. The localization suggests a specialized role in responding to acidic environments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nASIC3 functions through responding to changes in extracellular pH allowing sodium ions to enter cells when the pH decreases. It does not act solo and usually forms homomeric or heteromeric complexes with other ASIC subunits such as ASIC1 or ASIC2. This combination enhances its sensitivity and response diversity to varying acidic conditions contributing to processes like pain sensing and mechanotransduction. In muscle tissue ASIC3 plays a role in sensing metabolic changes that occur during intensive exercise.\u003cbr\u003e\nPathways\u003cbr\u003e\nASIC3 integrates into systems related to pain and mechanosensory pathways. It participates prominently in the nociceptive signaling pathway associated with the perception of pain induced by protons. ASIC3 works alongside proteins such as TRPV1 another ion channel known for its role in pain and thermal sensation. Interconnected with these pathways ASIC3 impacts physiological responses like hyperalgesia in acidic environments.\u003cbr\u003e\nASIC3 significantly contributes to conditions such as chronic pain and acid-induced pain from tissue injury or inflammation. It associates with migraines and inflammatory pain magnifying pain sensations under acidic conditions. In these contexts ASIC3 collaborates with proteins like the NaV1.7 sodium channel further influencing nerve excitability and pain perception. Targeting ASIC3 could potentially alleviate symptoms associated with these pain disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850313289897,"sku":"ab302776","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab302776","provider":"Iright","version":"1.0","type":"link"}