{"product_id":"abcam-ab302938","title":"Abcam, ab302938, Anti-Influenza A H7N9 Neuraminidase antibody [10F4]","description":"\u003cp\u003eSize: 10µg-TRIAL \/ 20µg \/ 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal Influenza A H7N9 Neuraminidase antibody. Suitable for ICC\/IF, I-ELISA and reacts with Transfected cell line - Influenza A, Influenza A samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:10F4,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Influenza A,\u003cbr\u003e\nApplications:ICC\/IF, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInfluenza A H7N9 Neuraminidase also known as NA or sialidase is an enzyme important in the viral replication process of the influenza virus. This protein with a molecular mass of approximately 47 kDa is expressed on the surface of the influenza A virus particles. Neuraminidase facilitates the removal of sialic acid residues from glycoproteins and glycolipids which is essential for the release of new viral particles from infected host cells. The enzymatic action is an important factor in the virus's spread within the respiratory tract of the host organism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe action of Influenza A H7N9 Neuraminidase assists in the completion of the viral life cycle. Neuraminidase in conjunction with hemagglutinin is part of a complex that allows the virus to attach and penetrate host cells efficiently. By cleaving sialic acid residues neuraminidase enables the newly formed viral particles to detach and spread facilitating infection progression. This protein's ability to disrupt cellular interactions highlights its role in viral pathogenicity an essential feature for the influenza virus's survival in host organisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuraminidase plays a significant part in the influenza viral entry and propagation pathways. Its interaction with hemagglutinin is important for the entry of the virus into host cells. Neuraminidase's activity supports the recycling of viral particles therefore contributing to the greater viral lifecycle network. Additionally its function links with pathways of immune evasion where it helps in avoiding the host's immune response primarily through altering host cell surface molecules and aiding in the spread of infection.\u003cbr\u003e\nNeuraminidase is closely associated with the pathogenesis of influenza particularly with influenza A and its subtypes such as H7N9. Neuraminidase inhibitors like oseltamivir target this protein to prevent the spread of influenza virus and mitigate symptoms. Resistance to such inhibitors can arise making the study of neuraminidase important for developing effective treatments. Neuraminidase's activity affects both the viral lifecycle and the host's immune response underlining its role in the interactions between influenza virus proteins and host immune components.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854709346473,"sku":"ab302938","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab302938","provider":"Iright","version":"1.0","type":"link"}