{"product_id":"abcam-ab303523","title":"Abcam, ab303523, Anti-TRAF5 antibody [EPR26205-1] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TRAF5 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26205-1,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRAF5 known as TNF receptor-associated factor 5 plays a role in cellular signaling pathways. This protein has a molecular mass of approximately 64 kDa. It is expressed in various tissues including lymphoid tissues and cells of the immune system. TRAF5 acts in signaling downstream of certain receptors like TNF receptor superfamily where it functions as an adapter protein that mediates signal transduction by interacting with other signaling molecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRAF5 influences immune cell functions and inflammatory responses. It forms part of a larger protein complex that regulates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Through this complex TRAF5 affects the transcription of genes involved in immune responses and cell survival. By modulating these processes TRAF5 helps maintain immune homeostasis and ensures proper immune response.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRAF5 is involved in signaling pathways such as NF-κB and JNK (c-Jun N-terminal kinase) pathways. TRAF5 interacts with proteins like TRAF2 and RIPK1 to propagate signals that lead to activation of these pathways. NF-κB pathway regulates inflammation and immune responses while JNK pathway plays a part in stress responses and apoptosis. The interaction of TRAF5 with these proteins and pathways positions it as an integral part of the immune signaling network.\u003cbr\u003e\nTRAF5 associates with autoimmune diseases including rheumatoid arthritis and lupus. Abnormal signaling through TRAF5 can lead to dysregulated immune responses contributing to these conditions. In rheumatoid arthritis for example TRAF5 may abnormally activate NF-κB pathway leading to enhanced inflammation. Moreover the interaction between TRAF5 and other proteins like TRAF1 influences the development of these diseases by affecting signal transduction which is important for understanding potential therapeutic targets in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851272868009,"sku":"ab303523","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab303523","provider":"Iright","version":"1.0","type":"link"}