{"product_id":"abcam-ab303537","title":"Abcam, ab303537, Anti-PPM1H antibody [EPR26028-53] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PPM1H antibody. Carrier free. Suitable for WB, IHC-P, IHC-Fr, IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26028-53,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-Fr, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for human IP\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein phosphatase Mg2+\/Mn2+ dependent 1H (PPM1H) is an enzyme that regulates cellular functions by removing phosphate groups from specific proteins. Known also as protein phosphatase 1H it has a molecular mass of approximately 55 kDa. It is expressed mainly in the brain but also in other tissues such as heart and kidney. PPM1H plays a role in intracellular signal transduction by dephosphorylating target proteins involved in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPPM1H modulates cellular signaling pathways impacting various physiological processes. It acts independently and does not form part of any known larger protein complex. Within cells PPM1H may interact with substrates involved in important cellular functions such as growth differentiation and apoptosis. Researchers propose that it acts as a regulatory phosphatase influencing cell cycle and stress response at a cellular level.\u003cbr\u003e\nPathways\u003cbr\u003e\nPPM1H is involved in signaling pathways like the TGF-beta and MAPK pathways. In these pathways it interacts with proteins such as SMAD2 and MAPK modulating their activity through dephosphorylation. The TGF-beta pathway plays an important role in regulating cell growth and differentiation while the MAPK pathway is essential for transmitting extracellular signals to cellular responses including gene expression.\u003cbr\u003e\nPPM1H has been implicated in nervous system disorders like Parkinson's disease and Alzheimer's disease. Studies suggest that altered PPM1H function can disrupt signaling pathways leading to neuronal degeneration. In Parkinson's disease PPM1H's connection to LRRK2 a protein kinase mutated in some hereditary cases shows potential implications in disease progression due to regulatory interactions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851619586217,"sku":"ab303537","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab303537","provider":"Iright","version":"1.0","type":"link"}