{"product_id":"abcam-ab305240","title":"Abcam, ab305240, Anti-UBR7 antibody [EPR26170-67] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UBR7 antibody. Carrier free. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra), IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26170-67,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUBR7 also known as E3 ubiquitin-protein ligase UBR7 is a protein encoded by the UBR7 gene. The molecular mass of UBR7 is approximately 82 kDa. This protein is expressed in various human tissues with notable higher levels in the liver kidney and heart. Mechanically UBR7 functions as an E3 ubiquitin ligase which means it plays a role in attaching ubiquitin molecules to specific substrates marking them for degradation by the proteasome.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUBR7 acts within cellular protein quality control by ensuring misfolded or damaged proteins are ubiquitinated for degradation. It is part of a larger ubiquitin-proteasome system which tightly controls protein turnover and homeostasis within the cell. This system helps maintain cell functions by regulating the abundance of key proteins involved in various cellular processes such as signal transduction and cell cycle control.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ubiquitin-proteasome system where UBR7 plays a significant role intersects with the cell cycle regulation and DNA damage response pathways. UBR7 interacts with proteins like p53 a well-known tumor suppressor playing a regulatory role in its stability and activity. Additionally it is involved in pathways concerning apoptosis contributing to programmed cell death when abnormal cells are detected.\u003cbr\u003e\nAberrations in UBR7 activity have been linked to cancer particularly related to disruptions in the regulation of p53. The dysregulation can lead to uncontrolled cell growth and tumor development. UBR7 also associates with neurodegenerative disorders where the accumulation of misfolded proteins due to impaired ubiquitination contributes to neuronal damage. Here its connection with proteins such as Tau is significant as abnormal ubiquitination patterns have been observed in cases of Alzheimer's disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851616407721,"sku":"ab305240","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab305240","provider":"Iright","version":"1.0","type":"link"}