{"product_id":"abcam-ab307370","title":"Abcam, ab307370, Anti-OGDH antibody [EPR27181-78] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal OGDH antibody. Carrier free. Suitable for Flow Cyt (Intra), ICC\/IF, IHC-Fr, IHC-P, WB and reacts with Mouse, Human, Rat, Transfected cell lysate - Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27181-78,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Mouse, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, WB, IHC-P, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOGDH also known as alpha-ketoglutarate dehydrogenase or a-ketoglutarate dehydrogenase is an enzyme that plays a significant role in metabolism. It catalyzes the conversion of alpha-ketoglutarate into succinyl-CoA and CO2 in the tricarboxylic acid (TCA) cycle also known as the Krebs cycle. The enzyme functions as a part of a multi-enzyme complex and has a molecular mass of approximately 1 MDa. OGDH is expressed in various tissues with higher levels typically found in the mitochondria of cells reflecting its role in cellular respiration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOGDH is critical for energy production by enabling the TCA cycle to proceed. It is a component of the alpha-ketoglutarate dehydrogenase complex consisting of multiple subunits which include E1 (OGDH itself) E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase). This complex functions to ensure the proper oxidation of metabolites important for maintaining cellular energy homeostasis. Proper regulation of OGDH activity impacts several metabolic pathways influencing cellular glucose and lipid metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nOGDH is integrally involved in the TCA cycle a central metabolic pathway that connects carbohydrate fat and protein metabolism. Alongside related enzymes like pyruvate dehydrogenase (PDH) and isocitrate dehydrogenase (IDH) OGDH contributes to the generation of NADH and FADH2 essential carriers in the electron transport chain. The interplay between these enzymes ensures the smooth functioning of aerobic respiration linking glycolysis and oxidative phosphorylation.\u003cbr\u003e\nOGDH has links to neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Abnormal activity of OGDH can lead to mitochondrial dysfunction a common feature observed in these disorders. The protein connects to pathways involving PDH dysfunction contributing to altered metabolic states seen in these conditions. Research continues to explore the potential of targeting OGDH in therapeutic strategies aimed at improving mitochondrial health and energy metabolism in affected patients.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851627483305,"sku":"ab307370","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab307370","provider":"Iright","version":"1.0","type":"link"}