{"product_id":"abcam-ab307414","title":"Abcam, ab307414, Anti-Ankyrin-B antibody [EPR26550-85]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Ankyrin-B antibody. Suitable for Dot, IHC-Fr, IHC-P, WB and reacts with Transfected cell lysate - Mouse, Rat, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26550-85,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WB, Dot, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAnkyrin-B also known as ANK1 and sometimes referred to as ankyrin 105 is a protein expressed in many tissues with significant presence in the brain heart and skeletal muscle. It has a molecular mass of approximately 215 kDa. This protein interacts with cytoskeletal elements and membrane proteins playing a major role in maintaining the stability and proper function of protein complexes at the plasma membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAnkyrin-B is essential for the localization and stability of ion channels and transporters. It forms part of a multi-protein complex that regulates the anchoring of these proteins to the cytoskeleton. In neurons ankyrin-B binds to cell adhesion molecules and ion channels affecting their function and distribution which is vital for maintaining cellular communication and structural integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nAnkyrin-B has significant roles in cardiac and neurological pathways. In the cardiac pathway it interfaces with proteins such as the sodium-calcium exchanger and Na+\/K+ ATPase essential for heart contractility and rhythm. In neuronal pathways ankyrin-B interacts with NCAM1 (Neural Cell Adhesion Molecule 1) which affects neuronal growth and guidance.\u003cbr\u003e\nAnkyrin-B is associated with cardiac arrhythmias and neurological disorders. Mutations in ankyrin-B can lead to long QT syndrome a disorder linked with irregular heartbeats. In neurological contexts alteration of ankyrin-B function associates with autism spectrum disorders. It has been found to interact with cardiac proteins like the sodium channel SCN5A which plays a role in maintaining a proper heartbeat.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850313224361,"sku":"ab307414","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab307414","provider":"Iright","version":"1.0","type":"link"}