{"product_id":"abcam-ab307656","title":"Abcam, ab307656, Anti-Piccolo antibody [EPR26840-80]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Piccolo antibody. Suitable for ICC\/IF, IHC-Fr, IHC-P and reacts with Rat, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26840-80,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Mouse,\u003cbr\u003e\nApplications:IHC-Fr, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPiccolo also known as PCLO is a protein with a molecular weight of about 550 kDa. It is located at the presynaptic active zone of neurons where it performs essential mechanical roles. The presence of Piccolo is universal especially in the brain and it plays a critical part in maintaining the proper structure and function of synapses. The protein contributes to the assembly and modulation of the presynaptic scaffold aiding neurotransmitter release and synaptic vesicle cycling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPiccolo interacts with multiple components of the synaptic machinery as it is part of the active zone complex. It associates with proteins such as Bassoon which together help to modulate neurotransmission efficacy. Piccolo contributes to the regulation of synaptic vesicle pools shaping the speed and timing of synaptic responses. These interactions emphasize its role in synaptic plasticity and maintain overall neural network stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nPiccolo engages in the synaptic vesicle cycle and neurotransmitter release pathway. It connects closely with proteins such as Synapsin and Rab3A involved in these processes. Through these pathways Piccolo aligns presynaptic components to facilitate rapid synaptic responses. Consequently it plays a role in processes like learning and memory where fast neurotransmitter release is necessary.\u003cbr\u003e\nPiccolo relates to neurological diseases like major depressive disorder and schizophrenia. Alterations in its expression or function impact synapse structure and may contribute to these conditions. It particularly intersects with proteins like Synapsin in the context of these disorders suggesting disruptions in neurotransmission can have wide-reaching effects on mental health and cognitive functions. These connections highlight the importance of Piccolo in maintaining normal neural function and its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850391900329,"sku":"ab307656","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab307656","provider":"Iright","version":"1.0","type":"link"}