{"product_id":"abcam-ab307698","title":"Abcam, ab307698, Anti-SAV1 antibody [EPR26085-80]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal SAV1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26085-80,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSAV1 also known as Salvador homolog 1 is a scaffold protein that plays an important role in regulating cell proliferation and apoptosis. This protein has a molecular weight of around 45 kDa and is widely expressed in various tissues throughout the body including the lung liver and heart. SAV1 contains two WW domains which facilitate interactions with other proteins critical for its function in signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSAV1 participates in the Hippo signaling pathway acting as a core component in the regulation of organ size by controlling cell growth and apoptosis. SAV1 forms a complex with other proteins such as MST1\/2 kinases and LATS1\/2 kinases promoting phosphorylation events that lead to the inhibition of the transcription co-activators YAP and TAZ. This inhibition prevents unchecked cell growth proving important for maintaining proper cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSAV1 is essential in both the Hippo and MAPK signaling pathways. In the Hippo pathway it interacts closely with MST1\/2 playing a role in pathway activation and signaling cascade propagation. In the MAPK pathway it indirectly influences cellular responses to external stress signals linking to proteins such as RAF1. The coordination within these pathways ensures regulated cell proliferation and stress response.\u003cbr\u003e\nSAV1 is linked to cancer and cardiac hypertrophy. When the Hippo pathway malfunctions due to altered SAV1 expression it can lead to uncontrolled cell growth and tumorigenesis. In some cancer types like hepatocellular carcinoma SAV1 dysfunction correlates with aggressive tumor traits. Moreover its alteration affects cardiac hypertrophy through its interactions with proteins like YAP influencing heart muscle enlargement due to stress which can lead to heart failure.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850347597993,"sku":"ab307698","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab307698","provider":"Iright","version":"1.0","type":"link"}