{"product_id":"abcam-ab307724","title":"Abcam, ab307724, Anti-CAPS2 antibody [EPR27004-72]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CAPS2 antibody. Suitable for WB, IHC-Fr and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27004-72,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCAPS2 also known as Calcium-Dependent Secretion Activator 2 is a protein that facilitates the release of neuropeptides and hormones by enhancing dense core vesicle exocytosis. The molecular mass of CAPS2 is approximately 145 kDa. It is expressed mainly in the brain including areas such as the cerebellum and hippocampus. CAPS2 acts by interacting with SNARE proteins which are essential for vesicle fusion and release processes at synaptic sites.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein CAPS2 plays an important role in synaptic transmission and the regulation of neurotransmitter secretion. It promotes the priming and fusion of vesicles allowing their contents to be released into the synaptic cleft. CAPS2 is often linked with other synaptic and regulatory proteins within a protein complex that orchestrates the efficient release of neurotransmitters and neuropeptides necessary for proper neuronal signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nCAPS2 takes part in the secretory pathway critical for synaptic activity and signaling in neurons. It interacts with important proteins such as synaptotagmin and Munc13 which are involved in the regulation of vesicle priming and exocytosis. Moreover CAPS2 is implicated in the calcium-dependent pathways that regulate neurotransmitter release enhancing functional communication between neurons.\u003cbr\u003e\nCAPS2 has been associated with autism spectrum disorders and schizophrenia. Studies indicate altered expression of CAPS2 may disrupt synaptic function potentially leading to these neurological conditions. The protein also interacts with voltage-gated calcium channels which are important for neuronal communication and are often involved in the pathophysiology of these disorders. Understanding CAPS2's involvement in these conditions offers potential targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850325676201,"sku":"ab307724","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab307724","provider":"Iright","version":"1.0","type":"link"}