{"product_id":"abcam-ab307733","title":"Abcam, ab307733, Anti-LAGE-1 antibody [EPR27371-91] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal LAGE-1 antibody. Carrier free. Suitable for IP, IHC-P, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27371-91,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLAGE-1 also known as CTAG2 is a cancer\/testis antigen that is expressed in tumors and normally only in the testis. Its precise molecular mass is approximately 22 kDa. LAGE-1 plays a mechanical role in cellular processes involving antigen presentation making it significant in the context of immune response modulation within neoplastic environments. The expression profile of LAGE-1 is characterized by its restriction to immune-privileged sites providing an opportunity for tumor-specific interventions due to its limited normal tissue expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLAGE-1 functions as part of a mechanism contributing to tumor immunogenicity. It participates in the presentation of peptides on the surface of cancer cells facilitating their recognition by T cells and subsequent immune targeting. LAGE-1 does not operate in isolation but may interact within a larger complex of similar antigens enhancing the immune system's ability to identify and combat malignancies.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of LAGE-1 in immune surveillance pathways is essential. It interacts with components of the major histocompatibility complex (MHC) class I antigen presentation pathway. By associating with proteins involved in this pathway LAGE-1 enhances the visibility of cancer cells to cytotoxic T lymphocytes. Other proteins such as LAGE-1's homolog MAGE-A share similar pathways suggesting overlapping roles in the formation of antigen complexes and subsequent immune recognition.\u003cbr\u003e\nLAGE-1 has strong associations with melanoma and non-small cell lung cancer. Its expression in these cancers makes it a target for immunotherapy approaches. In these contexts proteins like NY-ESO-1 which also belongs to the cancer\/testis antigen family are co-expressed with LAGE-1 indicating shared roles in tumor progression and immune evasion. These associations underline the potential of LAGE-1 as a marker for targeted cancer immunotherapy strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851758489769,"sku":"ab307733","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab307733","provider":"Iright","version":"1.0","type":"link"}