{"product_id":"abcam-ab308217","title":"Abcam, ab308217, Anti-Enterovirus D68 VP1 antibody [HL1997]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal Enterovirus D68 VP1 antibody antibody. Carrier free. Suitable for sELISA, WB and reacts with Recombinant full length protein - Enterovirus D68, Enterovirus D68, Transfected cell lysate - Enterovirus D68 samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1997,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Enterovirus D68,\u003cbr\u003e\nApplications:sELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEnterovirus VP1 also known as viral protein 1 is a structural protein of the enterovirus capsid. It has a mass of approximately 30 kilodaltons and plays an important role in virus assembly and host cell interaction. The protein is expressed on the viral surface and it is responsible for initial binding to the host cell receptors. This interaction facilitates the entry of the virus into cells initiating the infectious cycle. Enterovirus VP1 is highly conserved among different enterovirus serotypes which allows it to serve as a target for diagnostics and therapeutic interventions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein enables the structural integrity and infectivity of the virus. Enterovirus VP1 is a part of the viral capsid a protein complex that also includes VP2 VP3 and VP4. These proteins collectively protect the viral RNA genome and are involved in mediating interactions with the host immune system. The conformational structure of VP1 is recognized by neutralizing antibodies making it a focus point for vaccine development and antiviral drugs. Its expression and conformation can influence the antigenicity and serotype specificity of enteroviruses.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral actions revolving around host-pathogen interactions involve Enterovirus VP1. It plays a pivotal role in the cell entry mechanism through endocytic pathways. VP1 interacts with proteins such as ICAM-1 or PSGL-1 which serves as receptors in the early stages of viral pathogenesis. Additionally during viral uncoating and RNA release VP1 undergoes structural rearrangements that are essential for subsequent steps in the viral lifecycle and involve complex pathways like the host cell defense mechanism.\u003cbr\u003e\nAlterations in Enterovirus VP1 are significant in the context of ailments like hand foot and mouth disease and viral myocarditis. The protein's sequence variations can influence disease severity and transmission. Furthermore correlations have been established between the structural aspects of VP1 and host proteins involved in disease manifestation such as cellular kinases influencing viral replication. This protein's interactions and mutations contribute to the pathogenicity and epidemiology of enterovirus-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844262056105,"sku":"ab308217","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308217","provider":"Iright","version":"1.0","type":"link"}