{"product_id":"abcam-ab308224","title":"Abcam, ab308224, Anti-Plasminogen antibody [HL2071]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal Plasminogen antibody. Carrier free. Suitable for WB, IHC-P, ICC\/IF and reacts with Human, Rat, Mouse, Zebrafish, Cat samples. Immunogen corresponding to Recombinant Fragment Protein within Rhesus monkey PLG.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL2071,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human, Rat, Cat, Zebrafish,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Rhesus monkey PLG. The exact immunogen used to generate this antibody is proprietary information.P12545\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAngiostatin a fragment derived from plasminogen acts critically in inhibiting angiogenesis. It has a molecular mass of approximately 38 kDa. Angiostatin primarily derives from proteolytic cleavage of plasminogen within the vascular system. Expression of angiostatin occurs in various tissues but it is predominantly observed around tumor sites where it exerts its anti-angiogenic effects.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAngiostatin functions to inhibit the proliferation and migration of endothelial cells thereby blocking new blood vessel formation. It achieves this by binding to ATP synthase on the surface of endothelial cells. This protein operates as an isolated entity and does not typically form part of a larger complex. Angiostatin’s activity is essential in controlling physiological processes requiring reduced blood vessel development.\u003cbr\u003e\nPathways\u003cbr\u003e\nAngiostatin participates actively in the angiogenesis pathway interacting with factors like vascular endothelial growth factor (VEGF). It opposes pro-angiogenic signals by suppressing these pathways reducing the available nutrients to target tissues such as tumors. Angiostatin's role in the lysine-binding pathway also connects it to proteins like plasmin influencing fibrinolytic activity.\u003cbr\u003e\nAngiostatin associates strongly with cancer and ocular diseases like diabetic retinopathy. Its inhibitory effect on angiogenesis restricts the blood supply to tumors aiding in cancer treatment. In cancer angiostatin interacts with plasminogen activator inhibitor-1 (PAI-1) to modulate plasminogen activity. In ocular diseases angiostatin’s impact on abnormal blood vessel growth contributes to therapeutic strategies to manage these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860435357865,"sku":"ab308224","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308224","provider":"Iright","version":"1.0","type":"link"}