{"product_id":"abcam-ab308260","title":"Abcam, ab308260, Anti-Arx antibody [EPR27481-32]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-Arx antibody [EPR27481-32] (ab308260) is a rabbit monoclonal antibody detecting Arx in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC\/IF, mIHC . Suitable for  Human, Mouse, Rat . - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27481-32,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat, Mouse,\u003cbr\u003e\nApplications:mIHC, IHC-P, WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Arx antibody [EPR27481-32] (ab308260) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF), Multiplex IHC (mIHC) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of Arx?\u003cbr\u003e\nAnti-Arx [EPR27481-32] (ab308260) specifically detects a band for Arx (UniProt: Q96QS3) at a molecular weight of 58kDa.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR27481-32] also available for your convenience: ab308260, Carrier free -\u003cbr\u003e\nab308261\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Arx protein also known as Aristaless related homeobox is a transcription factor encoded by the ARX gene. Its molecular mass is approximately 55 kDa. Arx is mainly expressed in the brain and pancreas where it plays roles in development. The protein contains a homeobox domain which allows it to bind DNA and regulate transcription. In neurons Arx modulates the development and differentiation affecting various neuronal populations.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nArx influences the development of the central nervous system and pancreatic functions. Arx operates as part of a regulatory network that includes other transcription factors. It coordinates with these factors to manage the expression of genes required for neuronal subtype specification. In the pancreas Arx impacts the fate determination of endocrine cells particularly influencing alpha-cell development over beta-cell development.\u003cbr\u003e\nPathways\u003cbr\u003e\nArx is an important player in both the neuronal differentiation and endocrine development pathways. It interacts with proteins like Pax4 and Nkx2.2 within these pathways ensuring proper cell-type specification and differentiation. These pathways ensure the formation of diverse neuronal subclasses and appropriate distribution of endocrine cells in the pancreas.\u003cbr\u003e\nArx is associated with epilepsy and intellectual disability. Mutations in the ARX gene can lead to X-linked intellectual disability and contribute to the development of epilepsy. In both conditions Arx's interaction with proteins such as DCX (Doublecortin) and LIS1 is significant as these proteins are implicated in neuronal migration and cortical development. Hence alterations in Arx function can disrupt these processes leading to neurological disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848264208553,"sku":"ab308260","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308260","provider":"Iright","version":"1.0","type":"link"}