{"product_id":"abcam-ab308340","title":"Abcam, ab308340, Anti-Influenza A virus H1N1 NA Neuraminidase antibody [HL1108]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal Influenza A virus (strain A\/Wilson-Smith\/1933 H1N1) (Influenza A virus (strain A\/WS\/1933 H1N1)) Neuraminidase antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Transfected cell line - Influenza A samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1108,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Influenza A,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInfluenza A H1N1 Neuraminidase often called \"anti-NA\" is a surface glycoprotein expressed on the Influenza A virus including strains like H1N1 Singapore. This protein has a mass of about 470 kDa. Neuraminidase cleaves sialic acid residues from glycoproteins facilitating the spread of the virus by assisting in the release of virions from infected cells. This enzymatic action is essential for the efficient propagation of the influenza virus.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of Neuraminidase facilitates viral mobility and infectivity by preventing virion aggregation after budding from the host cell. While not part of a larger protein complex its role complements other viral surface proteins such as Hemagglutinin (HA) in mediating host cell entry and subsequent infection cycles. The interaction with Hemagglutinin is vital for maintaining viral infectivity balancing attachment to and release from host cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuraminidase activity is embedded in processes essential to the viral life cycle such as the respiratory epithelium invasion. The protein plays a role in the neuraminidase pathway distinct from but linked to the Hemagglutinin-mediated endocytosis pathway. These pathways ensure the virus manages effective host penetration and immune evasion strategies.\u003cbr\u003e\nThe activity of Neuraminidase is directly linked to diseases such as seasonal influenza and pandemics involving H1N1 strains including Influenza A: A\/Brisbane\/10\/07. The inhibition of Neuraminidase forms the basis for antiviral treatments like oseltamivir which aim to curb viral spread. The protein relates to disorders of immune response controlled partially by interactions with other viral proteins like Hemagglutinin which enhance or mitigate host immune activation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851859021993,"sku":"ab308340","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308340","provider":"Iright","version":"1.0","type":"link"}