{"product_id":"abcam-ab308363","title":"Abcam, ab308363, Anti-Lassa virus Nucleoprotein antibody [HL1392]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal NCAP antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Transfected cell line - Mammarenavirus lassaense samples. Immunogen corresponding to Synthetic Peptide within Lassa virus Josiah N.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1392,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mammarenavirus lassaense,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Lassa virus Josiah N. The exact immunogen used to generate this antibody is proprietary information.P13699\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNucleoprotein also known as NP is a structural protein that plays an important role in the assembly and genomic encapsidation of several viruses including influenza and hantavirus. It has a molecular mass that varies depending on the specific virus but typically ranges from 50 to 60 kDa. Nucleoprotein is expressed predominantly within the nuclear and cytoplasmic regions of infected host cells. It interacts directly with the viral RNA forming a ribonucleoprotein complex that facilitates the viral replication process.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNucleoprotein acts as an essential component in the viral lifecycle by aiding in the protection and packaging of viral RNA. It typically associates with other viral proteins to form a ribonucleoprotein complex which is necessary for viral replication and transcription. This complex ensures the encapsidation of the viral genome protecting it from nucleases and allowing proper assembly into new virions. Additionally nucleoprotein has been found to modulate host immune responses potentially aiding viral evasion of host defense mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nNucleoprotein participates in viral replication and transcription pathways particularly within the context of the host-virus interaction. It is associated with the replication machinery of the virus where it interacts with the polymerase complex which includes proteins such as polymerase basic 1 (PB1) and polymerase basic 2 (PB2). This interaction facilitates the synthesis of complementary RNA strands necessary for viral propagation and the production of viral proteins.\u003cbr\u003e\nNucleoprotein’s involvement is significant in conditions like viral hemorrhagic fevers such as those caused by hantavirus which lead to fever and thrombocytopenia. It plays a role in diseases by contributing to viral pathogenesis and influencing disease severity. The interaction of nucleoprotein with other proteins such as glycoproteins found in the viral envelope highlights its importance in the infectious cycle and its potential as a target for therapeutic interventions and vaccine development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851860332713,"sku":"ab308363","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308363","provider":"Iright","version":"1.0","type":"link"}