{"product_id":"abcam-ab308399","title":"Abcam, ab308399, Anti-Zika virus NS4B protein antibody [HL1664]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal Zika virus NS4B protein antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Transfected cell line - Zika virus, Zika virus, Transfected cell lysate - Zika virus samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1664,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Zika virus,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZika virus NS4B sometimes called NS4B nonstructural protein is an integral membrane protein with a mass of approximately 27 kDa. The protein localizes to the endoplasmic reticulum (ER) of infected cells. NS4B functions as an important component in the replication of the viral RNA genome. During viral replication NS4B alters the host cell membrane creating structures that favor viral replication. This protein also plays a role as a suppressor of the host's antiviral immune responses by interfering with the signaling pathways that control cytokines and interferons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNS4B interacts closely with other nonstructural proteins to form the viral replication complex a multi-protein assembly essential for efficient RNA synthesis. NS4B is known to modify the lipid composition of the ER membrane facilitating the formation of replication platforms essential for viral RNA synthesis. The protein also modulates cellular stress responses helping the virus to evade host immune surveillance. NS4B factors heavily in viral strategy to manipulate host cell processes ensuring successful viral replication and infection propagation.\u003cbr\u003e\nPathways\u003cbr\u003e\nNS4B influences the interferon signaling pathway and the unfolded protein response. It suppresses interferon production impacting the interferon-stimulated gene (ISG) response by modulating the host's immune signaling cascades. NS4B directly interacts with proteins such as NS4A and NS5 contributing towards the viral RNA polymerase activity. Its interactions stabilize the replication complex enhancing RNA genome synthesis. By inhibiting the unfolded protein response NS4B affects protein homeostasis allowing the virus to continue exploiting host resources.\u003cbr\u003e\nNS4B's function relates to Zika virus infection and it has associations with microcephaly in newborns. The protein plays a role in the virus’s pathogenic effects especially in neural cells contributing to neurodevelopmental disorders. Additionally NS4B impacts Guillain-Barré syndrome development linking it with immune-mediated damage to peripheral nerves. The interaction of NS4B with other proteins like NS1 helps modulate immune evasion strategies enhancing disease progression and infection severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851817111721,"sku":"ab308399","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308399","provider":"Iright","version":"1.0","type":"link"}