{"product_id":"abcam-ab308502","title":"Abcam, ab308502, Anti-MR1 antibody [EPR25671-79]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MR1 antibody. Suitable for WB, Flow Cyt and reacts with Transfected cell lysate - Human, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25671-79,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMR1 also known as the MR1 receptor or MR1 protein is an important player in the immune system. It weighs around 37 kilodaltons. This protein expresses prominently in many tissues such as the liver lymphoid tissues and the intestine. MR1 binds a range of small molecules derived from vitamin B metabolites. It presents these metabolites to a specific group of immune cells known as mucosal-associated invariant T (MAIT) cells leading to their activation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMR1 varies its mechanism by forming complexes with antigens that lack traditional peptide structure. It performs a major role in the immune response particularly through its interactions with MAIT cells. These cells represent an important intersection between innate and adaptive immunity responding rapidly to many pathogen-associated metabolites presented by MR1. This response contributes importantly to host protection especially against microbial infections.\u003cbr\u003e\nPathways\u003cbr\u003e\nMR1 is an integral component in the vitamin B antigen presentation pathway. It interacts significantly with other molecules involved in antigen presentation. MR1's function anchors it within the host-pathogen interaction pathways and connects with proteins like beta-2-microglobulin (β2M) which is important for surface expression. Its activity complements classical MHC pathways although it operates independently in presenting non-peptide antigens.\u003cbr\u003e\nMR1 contributes to understanding certain autoimmune conditions and infectious diseases. It connects to infectious diseases such as tuberculosis where MAIT cell activation plays a critical role in the immune response. Additionally MR1 has links to inflammatory bowel disease (IBD) a condition where gut microbiota activation of MAIT cells through MR1 may influence the disease outcome. Understanding its role in these diseases can provide insights into how MR1 or related proteins might be targeted for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850454257833,"sku":"ab308502","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308502","provider":"Iright","version":"1.0","type":"link"}