{"product_id":"abcam-ab308510","title":"Abcam, ab308510, Anti-CHCHD10 antibody [EPR26966-33]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CHCHD10 antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra), IP and reacts with Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26966-33,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, IP, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CHCHD10 protein also known as coiled-coil-helix-coiled-coil-helix domain containing 10 is a mitochondrial protein with a molecular weight of approximately 14 kDa. It is specifically localized within the intermembrane space of mitochondria and is expressed in various tissues with high levels in the brain heart and skeletal muscles. CHCHD10 plays a role in maintaining mitochondrial structure and function contributing to the stability and regulation of mitochondrial cristae.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe CHCHD10 protein participates in mitochondrial processes that regulate cellular energy production and apoptosis. It is part of a complex network within mitochondria interacting with other proteins to support mitochondrial DNA maintenance and oxidative phosphorylation. Its presence helps maintain cellular homeostasis by preventing mitochondrial dysfunction which can otherwise trigger oxidative stress and cellular damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nCHCHD10 is integral in the maintenance of mitochondrial quality control and respiratory pathways. It is involved in the mitochondrial inner membrane organizing system (MINOS) complex that is important for organizing and stabilizing mitochondrial membrane structure. CHCHD10 also interacts with proteins like OPA1 and CHCHD2 which are important for mitochondrial dynamics and energy regulation demonstrating its key role in these pathways.\u003cbr\u003e\nCHCHD10 mutations are linked to conditions like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The interaction between CHCHD10 and other mitochondria-related proteins like SOD1 and TDP-43 highlights its role in the pathogenesis of these neurodegenerative diseases. These mutations lead to mitochondrial dysfunction which contributes to the degeneration of motor neurons in ALS and the degeneration of frontal and temporal lobes in FTD.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855857307817,"sku":"ab308510","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab308510","provider":"Iright","version":"1.0","type":"link"}