{"product_id":"abcam-ab309397","title":"Abcam, ab309397, Human Apolipoprotein CII\/ApoC-II ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman Apolipoprotein CII\/ApoC-II ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Apolipoprotein CII\/ApoC-II in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 1.5 ng\/mL,\u003cbr\u003e\nRange:1.5 - 100 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman Apolipoprotein CII\/ApoC-II ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Apolipoprotein CII\/ApoC-II in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human Apolipoprotein CII\/ApoC-II coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nApolipoprotein CII also known as ApoC-II is an essential player in lipid metabolism. It is a 79 amino acid protein with an approximate mass of 8.9 kDa. ApoC-II is primarily expressed in the liver and secreted into the bloodstream where it associates with very-low-density lipoproteins (VLDLs) and chylomicrons. This protein serves an important mechanical role as an activator of lipoprotein lipase (LPL) an enzyme that hydrolyzes triglycerides into free fatty acids facilitating their uptake by tissues for energy production or storage.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nApoC-II plays a critical role in the metabolism of plasma triglycerides. As an important component of the lipoprotein complex it is necessary for effective lipid transport and triglyceride regulation. By activating lipoprotein lipase ApoC-II ensures efficient breakdown of triglycerides in the bloodstream aiding in maintaining lipid homeostasis. Without ApoC-II LPL lacks full activity leading to impaired triglyceride clearance and dyslipidemia.\u003cbr\u003e\nPathways\u003cbr\u003e\nApoC-II is integral to lipid metabolic pathways particularly in the catabolism of triglyceride-rich lipoproteins. It participates significantly in the lipid digestion pathway where it functions in concert with proteins like ApoE and ApoB which further assist in lipid binding and transport. ApoC-II's regulatory actions within these pathways are important for preventing the build-up of triglycerides in circulation contributing to a balance in energy storage and metabolism.\u003cbr\u003e\nMutations or deficiencies in ApoC-II function can lead to hyperlipoproteinemia type Ib a condition characterized by elevated plasma triglycerides and risk of pancreatitis. This disorder manifests due to defective activation of lipoprotein lipase highlighting the target's role alongside proteins such as LPL in lipid clearance. Additionally ApoC-II interactions with cholesterol transport proteins may influence atherosclerosis a condition where plaque builds up in arteries posing further cardiovascular risks.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855685374121,"sku":"ab309397","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab309397","provider":"Iright","version":"1.0","type":"link"}