{"product_id":"abcam-ab313372","title":"Abcam, ab313372, Anti-RG9MTD1 antibody [EPR27065-61]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TM10C antibody. Suitable for IHC-P, Flow Cyt (Intra), WB, ICC\/IF, IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27065-61,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for mouse and rat IHC-P.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRG9MTD1 also known as G9a or EHMT2 is an enzyme with a molecular mass of approximately 150 kDa. It is a histone methyltransferase that specifically targets lysine residues on histone H3. This methylation leads to chromatin modification and affects gene expression. RG9MTD1 is predominantly expressed in the nucleus of cells and is found in a variety of tissues across the body including the brain liver and kidney.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme RG9MTD1 contributes to the regulation of transcription by modifying chromatin structure. It is a component of the larger transcriptional repressor complex that includes other proteins like GLP (G9a-like protein). This complex mediates the dimethylation of histone H3 lysine 9 (H3K9me2) which plays a role in gene silencing. The presence of RG9MTD1 in this complex indicates its importance in controlling various genetic programs within different cell types.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of RG9MTD1 is important in key signaling pathways including the transforming growth factor-beta (TGF-beta) pathway and Wnt signaling. In the TGF-beta pathway RG9MTD1 interacts with proteins such as Smad to influence transcriptional responses impacting cell growth and differentiation. Similarly in the Wnt signaling pathway RG9MTD1 affects the expression of target genes that are essential for cell proliferation and embryonic development.\u003cbr\u003e\nThe deregulation of RG9MTD1 is connected to various cancers such as lung and colorectal cancer. Abnormal methylation patterns influenced by RG9MTD1 activity can lead to the silencing of tumor suppressor genes. Additionally neurodevelopmental disorders including autism spectrum disorders show links with RG9MTD1 due to its role in brain development and gene regulation. The interaction between RG9MTD1 and other proteins like SUV39H1 is significant in understanding its impact on disease pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850321940649,"sku":"ab313372","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab313372","provider":"Iright","version":"1.0","type":"link"}