{"product_id":"abcam-ab313388","title":"Abcam, ab313388, Anti-Klra8 antibody [EPR28281-49]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal KLRA8 antibody. Suitable for mIHC, IHC-P, Flow Cyt, ICC\/IF and reacts with Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28281-49,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:ICC\/IF, mIHC, IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKlra8 also known as Ly49H is a C-type lectin-like receptor found primarily on the surface of natural killer (NK) cells. It plays a significant role in immune surveillance against viral infections. The mass of Klra8 in its protein form is approximately 44 kDa. Expression of Klra8 is mainly in NK cells although some expression can also be observed in other immune cells under specific conditions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNatural killer cells utilize Klra8 to detect and destroy infected or transformed host cells. Klra8 plays an important role in recognizing ligands expressed by pathogens specifically certain strains of the mouse cytomegalovirus (MCMV). It is not a part of a larger protein complex. This receptor directly contributes to the cell-mediated cytotoxic response by NK cells facilitating the rapid elimination of threats to the host organism.\u003cbr\u003e\nPathways\u003cbr\u003e\nKlra8 operates within the immune response pathways critical for defense against viral infections. It interacts closely with components of innate immune signaling. Related proteins include DAP12 an adaptor protein that transmits activation signals from Klra8 leading to NK cell activation and subsequent target cell lysis. This pathway represents an important line of defense in the innate immune system.\u003cbr\u003e\nKlra8's role is particularly noted in the context of viral infections such as those caused by cytomegalovirus. Deficiencies or alterations in Klra8 expression have implications in viral susceptibility and immune regulation disorders. The receptor's connection to proteins such as DAP12 links it to other immune-mediated conditions where disruptions in NK cell function may result in increased vulnerability to viral pathogens or affect immune homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850402189481,"sku":"ab313388","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab313388","provider":"Iright","version":"1.0","type":"link"}