{"product_id":"abcam-ab313508","title":"Abcam, ab313508, Human XPNPEP1 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman XPNPEP1 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human XPNPEP1 in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Serum, Plasma,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 2.1 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman XPNPEP1 ELISA kit is an\u003cbr\u003e\nin vitro\u003cbr\u003e\nenzyme-linked immunosorbent assay for the quantitative measurement of human XPNPEP1 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human XPNPEP1 coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe XPNPEP1 protein also known as X-prolyl aminopeptidase 1 or aminopeptidase P functions as a cytosolic enzyme and possesses a zinc-binding motif. It cleaves N-terminal amino acids from peptides containing proline. This enzyme has a mass of approximately 65 kDa. XPNPEP1 is expressed in various tissues with high expression levels observed in the kidney and liver. It operates as a monomeric enzyme and requires metal ions for its catalytic activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nXPNPEP1 plays a role in protein and peptide metabolism by processing proline-containing substrates. It does not associate with any catalytic complexes but functions autonomously to modulate peptide availability and activity. Its enzymatic activity aids in regulating peptides involved in cellular signaling and function. XPNPEP1 helps maintain homeostasis by ensuring the correct processing and degradation of proline-containing peptides which can influence numerous physiological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nXPNPEP1 participates in the renin-angiotensin system (RAS) and the bradykinin degradation pathway. In the RAS XPNPEP1 modulates angiotensin molecules therefore impacting blood pressure regulation. It interacts with angiotensin-converting enzyme (ACE) within this system. In the bradykinin degradation pathway XPNPEP1 helps break down bradykinin peptides therefore preventing prolonged inflammatory responses and vascular permeability changes. Its activity is important in maintaining balance within these systems.\u003cbr\u003e\nXPNPEP1 has links to hypertension and renal diseases due to its involvement in blood pressure and fluid balance regulation. Its association with ACE makes it relevant to conditions like hypertension where ACE inhibitors are often treatment choices. Additionally changes in XPNPEP1 expression or activity can contribute to renal dysfunction given its significant expression in kidney tissues. Research on XPNPEP1 could lead to better understanding and treatment of these cardiovascular and renal conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843759362217,"sku":"ab313508","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab313508","provider":"Iright","version":"1.0","type":"link"}