{"product_id":"abcam-ab313743","title":"Abcam, ab313743, Anti-METTL16 antibody [EPR27236-78]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal METTL16 antibody. Suitable for IHC-P, ICC\/IF, Flow Cyt (Intra), WB and reacts with Human, Mouse, Rat samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27236-78,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMETTL16 or Methyltransferase-like protein 16 is a human enzyme known for catalyzing m6A methylation in RNA. The protein has a molecular mass of approximately 60 kDa. METTL16 is expressed in various tissues with higher levels in the liver kidney and brain. It also participates in the splicing and stabilization of RNA influencing gene regulation at the post-transcriptional level.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMETTL16 influences RNA stability and processing. It acts as a component of a larger ribonucleoprotein complex that interacts with a variety of RNA substrates. This protein primarily targets U6 spliceosomal RNA and MAT2A RNA to modulate their function and degradation affecting regulatory feedback mechanisms in cells. By targeting specific RNA molecules METTL16 can modulate cellular response to various stimuli at the RNA level.\u003cbr\u003e\nPathways\u003cbr\u003e\nMETTL16 plays an important role in RNA metabolism and gene expression regulation pathways. It cooperates with the S-adenosylmethionine (SAM) pathway which is vital for cellular methylation processes. METTL16 works alongside other m6A writers such as METTL3 and METTL14 to establish particular methylation marks on RNA influencing translation and stability which affects cell cycle regulation and differentiation.\u003cbr\u003e\nMETTL16 has implications in cancer and metabolic disorders. Dysregulation of its activity could lead to abnormal m6A methylation patterns contributing to tumorigenesis. Research has linked METTL16 to hepatocellular carcinoma where it interacts with other cancer-related proteins such as c-Myc affecting tumor growth and metabolism. Additionally its role in regulating MAT2A RNA associates it with metabolic anomalies implicating possible connections to diseases such as metabolic syndrome.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855873233065,"sku":"ab313743","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab313743","provider":"Iright","version":"1.0","type":"link"}