{"product_id":"abcam-ab313871","title":"Abcam, ab313871, Anti-Glycerol 3 Phosphate Dehydrogenase antibody [EPR25996-4]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GPDA antibody. Suitable for WB, IP, IHC-P and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25996-4,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlycerol 3-Phosphate Dehydrogenase (G3PDH) also known as G3P dehydrogenase and glycerol-3-phosphate dehydrogenase plays a mechanical role in the reversible redox conversion of dihydroxyacetone phosphate (DHAP) to glycerol 3-phosphate. The enzyme typically weighs around 40-50 kDa although the exact mass depends on isoform. G3PDH is expressed in various tissues with significant presence in the brain liver and skeletal muscle reflecting its involvement in energy metabolism. The mitochondrial and cytosolic forms add to its versatility in cellular compartments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme is critical for lipid and carbohydrate metabolism engaging extensively in energy homeostasis. G3PDH exists as part of a complex to facilitate its role in mitochondrial electron transport. It acts as a shuttle transferring electrons from cytosolic NADH into the mitochondria. This electron transport is essential for synthesizing ATP thereby linking metabolic pathways within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nGlycerol-3-phosphate dehydrogenase participates actively in the glycerol phosphate shuttle and lipid biosynthesis pathways. It pairs functionally with its partner the mitochondrial glycerol 3-phosphate dehydrogenase (mG3PDH) to support efficient energy production and lipid storage. Additionally this enzyme relates closely to proteins like NADH dehydrogenase playing a role in electron transport chains in mitochondria critical for bioenergetics.\u003cbr\u003e\nG3PDH has connections to metabolic conditions such as obesity and diabetes. Impaired function of this enzyme can lead to disruptions in metabolic pathways which can contribute to these diseases. It also holds significance in cancer metabolism with altered expression of G3PDH seen in various tumors. The enzyme's relation to proteins like mG3PDH highlights its role in metabolic syndrome and associated pathologies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850302181545,"sku":"ab313871","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab313871","provider":"Iright","version":"1.0","type":"link"}