{"product_id":"abcam-ab313878","title":"Abcam, ab313878, Anti-SA2 (isoform-2) antibody [EPR26892-61] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SA2 antibody. Carrier free. Suitable for ChIP-seq, Flow Cyt (Intra), IHC-P, WB, IP, ICC\/IF and reacts with Human, Mouse, Rat, Transfected cell line - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26892-61,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:ICC\/IF, ChIP-seq, Flow Cyt (Intra), IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for human IHC-P.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab313878 is the carrier-free version of\u003cbr\u003e\nab313877\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSA2 isoform-2 also known as Structural Maintenance of Chromosomes Protein 3 (SMC3) is a component of the cohesin complex which plays a critical role in the cohesion of sister chromatids. SA2 isoform-2 has a mass of approximately 150 kDa. It is expressed in a variety of tissues with significant expression in dividing cells where its function contributes to proper cell division and chromosome segregation. The capacity of SA2 isoform-2 to bind and stabilize cohesion complexes in the nucleus is fundamental for maintaining genomics stability during the cell cycle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSA2 isoform-2 supports the integrity of chromatid pairing. As part of the cohesin complex it interacts with other cohesin subunits such as SMC1 SMC3 and RAD21. This complex regulates chromosome architecture by facilitating loop formation and sister chromatid cohesion. These functionalities are essential during the cell cycle particularly in the S and G2 phases ensuring that chromatid pairs do not prematurely separate before mitosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSA2 isoform-2 plays an important role in cell cycle regulation and DNA damage repair pathways. Within the cell cycle its function is connected to the loading and stabilization of cohesin complexes that enable proper chromosome alignment and segregation during mitosis. In DNA repair pathways it associates with proteins like PDS5 and WAPL which contribute to modulating cohesin dynamics and ensuring successful repair of DNA double-strand breaks. These activities are pivotal to preserving chromosomal stability.\u003cbr\u003e\nMutations or dysfunctions in SA2 isoform-2 are linked to cohesinopathies including Cornelia de Lange Syndrome and certain cancer types. In Cornelia de Lange Syndrome mutations affecting SA2 isoform-2 or its interacting partners such as NIPBL result in developmental abnormalities and intellectual disability. In cancer aberrant expression or malfunctions in components of the cohesin complex which includes SA2 isoform-2 can lead to genomic instability promoting tumorigenesis and driving cancer progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851606544553,"sku":"ab313878","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab313878","provider":"Iright","version":"1.0","type":"link"}