{"product_id":"abcam-ab314025","title":"Abcam, ab314025, Anti-ACAA2 antibody [12F4]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal ACAA2 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human 3-ketoacyl-CoA thiolase, mitochondrial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:12F4,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human 3-ketoacyl-CoA thiolase, mitochondrial.P42765\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nACAA2 also known as acetyl-CoA acyltransferase 2 or 3-ketoacyl-CoA thiolase plays an important role in the mechanical process of fatty acid oxidation. It functions in the mitochondria where it catalyzes the final step of the beta-oxidation pathway facilitating the conversion of acetoacetyl-CoA to two molecules of acetyl-CoA. This protein has a known mass of approximately 43 kDa. ACAA2 is expressed in tissues with high energy demands such as the liver heart and muscle highlighting its significance in energy metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme catalyzes reactions in energy metabolism by breaking down fatty acids to generate energy. ACAA2 functions as part of the complex mitochondrial fatty acid beta-oxidation machinery. This process supports energy production particularly under conditions of carbohydrate depletion. The production of acetyl-CoA by ACAA2 is important for the TCA cycle through which cells generate ATP the primary energy carrier.\u003cbr\u003e\nPathways\u003cbr\u003e\nAcetyl-CoA acyltransferase 2 plays significant roles in both the fatty acid beta-oxidation and ketogenesis pathways. In the beta-oxidation pathway it works together with other enzymes like CPT1A and HADHB to efficiently break down fatty acids. In ketogenesis acetyl-CoA units produced by ACAA2 are directed towards the formation of ketone bodies which serve as an alternative energy source for the brain and muscles during fasting or prolonged exercise.\u003cbr\u003e\nACAA2 has connections to metabolic disorders particularly fatty acid oxidation disorders and diabetes. Deficiency in ACAA2 activity can result in accumulation and impaired degradation of fatty acids leading to metabolic imbalances. This enzyme also interacts with related proteins such as ACADM in the context of these metabolic diseases. Disruptions in ACAA2 function can face links to mitochondrial dysfunctions that contribute to diabetes due to its role in energy production and regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850356773033,"sku":"ab314025","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314025","provider":"Iright","version":"1.0","type":"link"}