{"product_id":"abcam-ab314131","title":"Abcam, ab314131, Anti-B4GALNT1 antibody [EPR28064-64] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal B4GALNT1 antibody. Carrier free. Suitable for WB, IHC-P, Dot and reacts with Human, Mouse, Rat, Recombinant fragment - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28064-64,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, Dot, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for mouse IHC-P, rat IHC-P\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab314131 is the carrier-free version of\u003cbr\u003e\nab314130\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nB4GALNT1 also known as beta-14-N-acetylgalactosaminyltransferase 1 is an enzyme that plays a role in the biosynthesis of gangliosides. It has a molecular mass of approximately 56 kDa. B4GALNT1 catalyzes the transfer of N-acetylgalactosamine to substrates in the Golgi apparatus which facilitates the formation of gangliosides. This enzyme exhibits expression mainly in the central nervous system and several other tissues reflecting its role in the development and function of neural cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme contributes to the synthesis of complex gangliosides. B4GALNT1 does not work alone; instead it integrates into a system of glycosylation pathways involving other glycosyltransferases forming a complex network that tailors the composition of glycan structures on lipids and proteins. This activity influences cell recognition adhesion and signaling processes important for neurodevelopment and synapse formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nB4GALNT1 influences the ganglioside biosynthetic pathway an important aspect for proper neuronal function. This pathway involves collaboration with other proteins such as GM2 synthase which cooperates in the addition of sugar residues at various stages of glycolipid formation. These interactions ensure the synthesis of diverse ganglioside molecules within nerve cell membranes which are vital in modulating cellular interactions and signal transduction.\u003cbr\u003e\nAlterations in B4GALNT1 function have connections to neurological disorders such as Alzheimer's disease and certain types of gangliosidosis. Perturbations in its enzymatic activity can disrupt normal ganglioside composition affecting membrane dynamics and cell signaling. Phenomena linked to other glycosylation enzymes like GM3 synthase also illustrate disease pathways impacted by aberrant glycan synthesis highlighting B4GALNT1's indirect influence on these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851430416553,"sku":"ab314131","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314131","provider":"Iright","version":"1.0","type":"link"}