{"product_id":"abcam-ab314231","title":"Abcam, ab314231, Anti-RS1 antibody [EPR28513-78]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RS1 antibody. Suitable for ICC\/IF, WB, IP, IHC-P, IHC-Fr and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28513-78,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, IP, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe RS1 protein also known as retinoschisin plays a critical role in cellular adhesion and retinal structure maintenance. It has a molecular mass of approximately 24 kDa. Scientists have observed RS1 expression specifically in the retina suggesting it has a specialized function in retinal health and vision. The protein exists in a dimeric form allowing it to interact efficiently with cellular membranes and extracellular matrices. Its expression is not found in frozen retina samples suggesting changes occur post-mortem or under preservation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRS1 is involved in maintaining the structural organization of the retinal layers. It participates in forming a protein complex that helps maintain the extracellular space and regulates cellular adhesion within the retina contributing to the integrity and stability of retinal architecture. The structure of the retina is important for proper signal transduction related to visual processing. The RS1 protein acts as a stabilizing factor reducing retinal detachment and disruptions that can impact vision clarity and focus.\u003cbr\u003e\nPathways\u003cbr\u003e\nRetinoschisin interacts with cellular adhesion pathways and signal transduction within retinal cells. This protein appears to influence the Wnt signaling pathway which plays a role in cell-to-cell communication in the retina. Additionally RS1 associates with the neuropilin protein family which includes proteins involved in axon guidance and vascular patterning therefore influencing the development and maintenance of the retinal structure. These pathways highlight the potential impact of RS1 on visual processing and retinal health.\u003cbr\u003e\nRS1 mutations have links to X-linked juvenile retinoschisis a retinal disorder leading to vision impairment in males. This disorder manifests as splitting of the retinal layers affecting visual acuity. RS1 interacts with laminin a protein involved in the extracellular matrix and disruptions in this interaction may contribute to disease pathogenesis. Research has also observed RS1's role in retinitis pigmentosa where progressive vision loss occurs and understanding its function provides insights into therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850309390505,"sku":"ab314231","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314231","provider":"Iright","version":"1.0","type":"link"}