{"product_id":"abcam-ab314718","title":"Abcam, ab314718, Human RAET1E ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman RAET1E ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human RAET1E in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.43 ng\/mL,\u003cbr\u003e\nRange:0.43 - 100 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman RAET1E ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human RAET1E in serum (human RAET1E concentration is low in normal serum\/plasma, and may not be detectable in this assay), plasma and cell culture supernatants. This assay employs an antibody specific for human RAET1E coated on a 96-well plate.\u003cbr\u003e\nThis ELISA kit shows no cross-reactivity with the following cytokines tested: human Coagulation Factor X, CHMP2B, Contactin-3, Cortactin, CrkL, Cyr61\/CCN1, DAPP1, Dynactin Subunit 1\/DCTN1, DFF45\/ICAD, DRAK1, GRAP2, GRK5, Hydroxyacid Oxidase1\/HAO-1, LRIG1, MMP-12, NCK1, Nectin-2\/CD112, Nesfatin1\/Nucleobindin-2, Neurogranin, Nrf2, NUDT5, Nucleoporin NUP85, PAR1, Pancreatic Polypeptide\/PP, Peroxiredoxin 2, PSMA1, PU.1\/Spi-1, RalA, RCOR1\/CoREST, Serpin B8, SH2D1A, SHP-1, Siglec-6\/CD327, SorCS3, THAP11, UNC5H3, VAMP-1, VAMP-2, PBEF\/Visfatin\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAET1E also known as UL16-binding protein 4 (ULBP4) is a member of the MHC class I-related molecules. It has a molecular mass of approximately 31 kDa. RAET1E is part of the family of proteins that acts as a ligand for the NKG2D receptor found on the surface of natural killer (NK) cells. In terms of expression RAET1E is present on the surface of various cell types especially in stressed transformed or virus-infected cells where it signals cellular distress to immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRAET1E plays a role in immune surveillance. It is involved in the activation of NK cells when it binds to the NKG2D receptor. This interaction is part of the body's defense mechanism against transformed or infected cells. RAET1E operates in isolation rather than as part of a larger protein complex which allows it to independently initiate the immune response when detecting harmful cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nRAET1E functions within the innate immune response pathway. It works closely with the NKG2D signaling pathway which is important for the activation of cytotoxic activities in immune cells. RAET1E through its binding to NKG2D facilitates the destruction of malignant cells. This connection places RAET1E alongside other similar NKG2D ligands such as MIC and other ULBP family proteins which contribute to the activation of NK and T cells.\u003cbr\u003e\nRAET1E is linked to various cancer types and infectious diseases. Its expression on the surface of tumor cells can signal NK cells to target and destroy these potentially harmful cells. In certain cancers the loss or reduction of RAET1E expression may allow tumor cells to escape immune detection. In viral infections the upregulation of RAET1E on infected cells assists in the clearance of viruses by NK cells. Both in cancer and viral infections proteins like RAET1E and NKG2D play an important part in the immune system's defensive strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843771191465,"sku":"ab314718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314718","provider":"Iright","version":"1.0","type":"link"}