{"product_id":"abcam-ab314764","title":"Abcam, ab314764, Anti-TMEM41B antibody [EPR28149-41] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TM41B antibody. Carrier free. Suitable for WB, IP and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28149-41,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab314764 is the carrier-free version of\u003cbr\u003e\nab314763\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM41B also known as Transmembrane Protein 41B is part of the ER membrane protein complex that plays a fundamental role in various cellular processes. It is a 35 kDa protein located predominantly in the endoplasmic reticulum membrane. TMEM41B shows expression in many tissues including heart brain kidney and skeletal muscle suggesting its important role across different biological systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein functions in autophagy a process essential for cellular homeostasis and survival during stress conditions. TMEM41B associates with the ER-phagy complex where it is important for the regulation and expansion of autophagosomes. It works in coordination with proteins like VMP1 and ATG9A supporting the recruitment and stability of autophagosomal membranes which impacts the cell's ability to recycle and reuse cellular components.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM41B has a significant involvement in the autophagy and lipid metabolism pathways. It interacts with other proteins such as VMP1 and ATG9A mediating the lipid mobilization necessary for efficient autophagosome formation. These interactions ensure that TMEM41B plays a role in the homeostatic regulation of lipids and proteins contributing to proper cellular function and response to metabolic demands.\u003cbr\u003e\nTMEM41B associates with conditions like neurodegeneration and certain viral infections. Alterations or deficiencies in TMEM41B can impact its autophagic function potentially leading to neurodegenerative diseases where protein aggregates accumulate as seen in relation to ATG9A dysfunction. Additionally studies link TMEM41B to the flavivirus life cycle suggesting its necessity in viral replication processes. These connections highlight its potential as a therapeutic target in disease management.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851935109289,"sku":"ab314764","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314764","provider":"Iright","version":"1.0","type":"link"}