{"product_id":"abcam-ab314856","title":"Abcam, ab314856, Anti-ADAMTS4 antibody [EPR24094-30]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ADAMTS4 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24094-30,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nADAMTS4 also known as aggrecanase-1 is a protein responsible for extracellular matrix degradation. It weighs approximately 90 kDa. This metalloproteinase is expressed in various tissues including cartilage and synovial tissue. It cleaves aggrecan a core protein of the proteoglycan into fragments impacting the integrity and function of the cartilage matrix. It is secreted as a latent enzyme and undergoes activation in the extracellular space.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nADAMTS4 influences tissue remodeling through the breakdown of cartilage. It contributes to the disassembly of aggrecan and other matrix components influencing extracellular matrix turnover. As part of a group of similar enzymes it plays a role in proteolytic processes important for normal tissue maintenance and repair. Its actions affect the balance between matrix synthesis and degradation which is important for maintaining tissue homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nADAMTS4 participates in pathways such as the inflammation-related cytokine signaling and the degradation of the extracellular matrix. This protein interacts closely with ADAMTS5 contributing to matrix degradation and modulation of inflammatory processes. In these pathways the balanced activity of ADAMTS4 is essential for proper cartilage function and the resolution of inflammation in tissues.\u003cbr\u003e\nADAMTS4 is notably linked to osteoarthritis and rheumatoid arthritis. These conditions involve excessive cartilage breakdown where ADAMTS4 and ADAMTS5 contribute significantly to disease progression through aggrecan degradation. Understanding the activity and regulation of ADAMTS4 offers insights into potential therapeutic strategies for managing cartilage degeneration and inflammatory joint diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850336129193,"sku":"ab314856","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314856","provider":"Iright","version":"1.0","type":"link"}