{"product_id":"abcam-ab314942","title":"Abcam, ab314942, APC Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal","description":"\u003cp\u003eSize: 10µL-TRIAL \/ 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal PDGFR beta antibody - conjugated to APC. Suitable for Flow Cyt (Intra) and reacts with Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:Y92,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:APC,\u003cbr\u003e\nExcitation\/Emission:Ex: 650nm, Em: 660nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDGFR alpha and PDGFR beta are receptor tyrosine kinases also known as CD140a and CD140b. Both receptors have a molecular mass of about 180 kDa. PDGFR alpha is expressed in a variety of tissues including placenta astrocytes and vascular smooth muscle cells. PDGFR beta is more specific to fibroblasts smooth muscle cells and in the vascular system. These receptors bind platelet-derived growth factors (PDGFs) and become activated through dimerization and autophosphorylation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese receptors drive cellular processes like proliferation differentiation and migration. PDGFR alpha and beta operate as a significant part of a receptor complex. They modulate responses in mesenchymal cells and influence developmental pathways. In the vasculature system these receptors play roles in maintaining structure and function of blood vessels. Alterations in receptor activities can affect development of tissues and organs.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDGFR alpha and beta are key players in the PI3K-Akt signaling pathway and MAPK pathway. The activation of these pathways leads to cellular processes like survival and growth. PDGFR activity often interacts with other proteins such as SHP-2 RAS and Akt. These interactions contribute to the regulation of cellular responses to external growth signals embedding PDGFR in a web of intracellular cascade systems.\u003cbr\u003e\nPDGFRs have linkage to conditions like cancer and fibrotic diseases. Aberrant PDGFR alpha activity has connections to glioblastoma while PDGFR beta alterations often relate to systemic sclerosis. These receptors can work alongside proteins like VEGF and TGF-beta within these diseases. Their dysregulation leads to pathological angiogenesis and abnormal cell proliferation making them targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860621938857,"sku":"ab314942","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab314942","provider":"Iright","version":"1.0","type":"link"}