{"product_id":"abcam-ab315092","title":"Abcam, ab315092, Anti-Pan Cav2 antibody [EPR28073-84]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CACNA1A antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Mouse, Rat, Transfected cell lysate - Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28073-84,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPan Cav2 also known as Cav2 channels or voltage-gated calcium channels of the Cav2 family function mechanically to facilitate the influx of calcium ions through cellular membranes in response to membrane depolarization. These channels are important for converting electrical signals into calcium signals which play a big role in various cellular processes. Cav2 channels typically compose of the α1 subunit and several auxiliary subunits. The α1 subunit has an approximate mass of 190-250 kDa. Cav2 channels express widely throughout the nervous system including in neurons of the brain and spinal cord and also in cardiac and skeletal muscle cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCav2 channels play key roles in neurotransmitter release muscle contraction and hormone secretion. These channels form part of multiprotein complexes that involve various auxiliary subunits which modulate their function and localization. Through their regulation of calcium influx Cav2 channels critically impact synaptic transmission and plasticity in neuronal communication. They also contribute to excitation-contraction coupling in muscle cells enabling the precise control of muscle actions.\u003cbr\u003e\nPathways\u003cbr\u003e\nCav2 channels heavily influence calcium signaling pathways and synaptic plasticity pathways. Within the calcium signaling pathway their activity directly alters intracellular calcium concentrations which modulate downstream signaling cascades. These channels closely interact with proteins such as SNARE proteins and synaptotagmin in neurotransmitter release. In pathways related to synaptic plasticity Cav2 channels influence long-term potentiation impacting learning and memory processes.\u003cbr\u003e\nCav2 channel dysfunction associates with neurological disorders such as migraine and epilepsy. Aberrant expression or mutation of Cav2 channel components disrupts normal neural excitation leading to these disorders. The channels also connect with auxiliary proteins such as α2δ subunits that can alter pain pathways implicating them in certain pain disorders. Moreover irregularities in Cav2 channel function may link to cardiac arrhythmias through interactions with cardiac proteins responsible for proper heartbeat rhythm.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850293432489,"sku":"ab315092","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab315092","provider":"Iright","version":"1.0","type":"link"}