{"product_id":"abcam-ab315796","title":"Abcam, ab315796, Anti-Homeobox protein cut-like 2 antibody [EPR26509-79]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CUX2 antibody. Suitable for IHC-P and reacts with Mouse, Rat, Transfected cell line - Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26509-79,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Homeobox protein cut-like 2 also known as CDP CUX2 or Clox functions as a transcription factor and plays a critical role in regulating gene expression. Mechanically it binds to specific DNA sequences to influence the transcription of target genes. CUX2 has a molecular mass of approximately 150 kDa. Researchers observe its expression in the brain particularly in developing neocortex as well as the adult testis and lymph nodes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHomeobox protein cut-like 2 is involved in the development of the nervous system and the regulation of cell growth and differentiation. It is not part of a larger complex but interacts with other transcription factors to modulate these processes. The protein's involvement is significant in neural development impacting neurogenesis and neural patterning. It coordinates with DNA repair pathways as well.\u003cbr\u003e\nPathways\u003cbr\u003e\nHomeobox protein cut-like 2 integrates into neural developmental pathways and cell cycle regulation. In neural development it interacts with other factors like NEUROD1 to influence neuronal differentiation. In cell cycle control it participates in pathways such as the cell proliferation pathway interacting with proteins like p27Kip1 to regulate cell cycle progression and ensure proper cell growth.\u003cbr\u003e\nHomeobox protein cut-like 2 has an association with neurodevelopmental disorders and cancer. Altered expression or mutations in the protein can lead to developmental abnormalities including neural developmental issues. In cancer abnormal regulation can contribute to tumorigenesis especially in brain-related cancers. It might interact with proteins associated with these conditions such as the tumor suppressor protein p53 indicating its significance in disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850369126569,"sku":"ab315796","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab315796","provider":"Iright","version":"1.0","type":"link"}