{"product_id":"abcam-ab315878","title":"Abcam, ab315878, Anti-MCPIP1 antibody [EPR26062-59] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MCPIP1 antibody. Carrier free. Suitable for Dot, WB and reacts with Synthetic peptide - Human, Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26062-59,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab315878 is the carrier-free version of\u003cbr\u003e\nab315877\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MCPIP1 (Monocyte Chemotactic Protein-Induced Protein 1) also known by the name Regnase-1 is a protein involved in RNA degradation and inflammation regulation. It acts as an RNase specifically targeting mRNAs for degradation impacting gene expression post-transcriptionally. The protein weighs around 66 kDa and shows expression in various tissues including heart spleen and macrophages. MCPIP1 also demonstrates notable expression in response to external stimuli like lipopolysaccharides.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMCPIP1 modulates the immune response and inflammation by degrading mRNA of cytokines. Its action helps in controlling inflammation and immune response duration. MCPIP1 interacts with cellular complexes that manage mRNA stability including those involved in decay processes. This activity positions MCPIP1 as a regulator in the production of pro-inflammatory cytokines contributing to the cellular response to external pathogens.\u003cbr\u003e\nPathways\u003cbr\u003e\nMCPIP1 functions within the inflammatory and immune signaling pathways. It is involved in the MAPK pathway which regulates gene expression in response to stress and cytokines. MCPIP1 also interacts with proteins such as TNF-alpha and IL-6 linking it to the inflammatory signaling cascade. These interactions highlight MCPIP1's role in mediating immune and inflammatory pathways contributing to maintaining cellular homeostasis.\u003cbr\u003e\nMCPIP1 connections relate to inflammatory diseases and autoimmune disorders. Aberrant expression or malfunction of MCPIP1 associates with pathological conditions including rheumatoid arthritis and systemic lupus erythematosus. The regulation of cytokines by MCPIP1 positions it centrally in these conditions as inappropriate levels of proteins like IL-6 and TNF-alpha contribute to disease progression. Consequently MCPIP1 serves as a potential therapeutic target in managing inflammation-driven diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851267133609,"sku":"ab315878","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab315878","provider":"Iright","version":"1.0","type":"link"}