{"product_id":"abcam-ab315884","title":"Abcam, ab315884, Anti-HDAC11\/HD11 antibody [EPR26890-83] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HDAC11\/HD11 antibody. Carrier free. Suitable for WB, ChIP-seq, IP and reacts with Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26890-83,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IP, WB, ChIP-seqSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab315884 is the carrier-free version of\u003cbr\u003e\nab315883\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHDAC11 also known as HD11 is a unique member of the histone deacetylase family. HDAC11 is an enzyme involved in removing acetyl groups from lysine residues on histone tails affecting chromatin structure and gene expression. It has a molecular mass of approximately 39 kDa. You can find HDAC11 expressed in various tissues but it shows higher expression levels in brain heart skeletal muscles and kidneys indicating its significance in these organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHDAC11 participates in the regulation of gene expression by modulating histone acetylation levels. It often functions as a part of large protein complexes that include other histone deacetylases and transcriptional co-repressors. By altering acetylation status HDAC11 can influence epigenetic regulation and thereby affect numerous cellular processes such as cell cycle progression differentiation and apoptosis. Its activity contributes to maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nHDAC11 plays a role in key signaling pathways such as the DNA damage response and inflammatory pathways. In the DNA damage response pathway HDAC11 interacts with proteins like HDAC1 and HDAC2 which are essential for DNA repair processes. Additionally in inflammatory pathways HDAC11 regulates cytokine expression and immune cell function highlighting its role in immune response modulation.\u003cbr\u003e\nResearchers have linked HDAC11 to cancer and autoimmune diseases. Its abnormal expression or activity has associations with various cancer types including brain and kidney cancers where it potentially influences tumor progression through interaction with proteins like p53. In autoimmune diseases HDAC11 affects immune cell regulation and cytokine production interacting with immune-related proteins which may contribute to disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851931373737,"sku":"ab315884","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab315884","provider":"Iright","version":"1.0","type":"link"}