{"product_id":"abcam-ab316251","title":"Abcam, ab316251, Human LAIR2 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman LAIR2 ELISA Kit is a single-wash 90-min Simplestep used to quantify Human LAIR2 with a sensitivity of 2.628 pg\/ml. The assay uses a simple mix-wash-read protocol with just one incubation and one wash step. - Colorimetric Sandwich ELISA - 450 nm readout : works on any standard plate reader - Design your own immunoassay: we also offer the conjugation-ready antibody pair\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Serum, EDTA Plasma, Urine, Cell culture media, Heparin Plasma, Citrate plasma,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 2.628 pg\/mL,\u003cbr\u003e\nRange:10.156 - 650 pg\/mL,\u003cbr\u003e\nAssay time:1h 30m,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman LAIR2 SimpleStep ELISA\u003cbr\u003e\nkit is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of LAIR2 protein in Serum, EDTA Plasma, Cit Plasma, Hep Plasma, Urine, Cell culture media. Quantitate Human LAIR2 with 2.628 pg\/ml sensitivity.\u003cbr\u003e\nSimpleStep ELISA\u003cbr\u003e\ntechnology employs capture antibodies conjugated to an affinity tag that is recognized by the monoclonal antibody used to coat our SimpleStep ELISA\u003cbr\u003e\nplates. This approach to sandwich ELISA allows the formation of the antibody-analyte sandwich complex in a single step, significantly reducing assay time. See the SimpleStep ELISA\u003cbr\u003e\nprotocol summary in the image section for further details. Our SimpleStep ELISA\u003cbr\u003e\ntechnology provides several benefits:\u003cbr\u003e\n-Single-wash protocol reduces assay time to 90 minutes or less\u003cbr\u003e\n-High sensitivity, specificity and reproducibility from superior antibodies\u003cbr\u003e\n-Fully validated in biological samples\u003cbr\u003e\n-96-wells plate breakable into 12 x 8 wells strips\u003cbr\u003e\nA 384-well SimpleStep ELISA\u003cbr\u003e\nmicroplate (\u003cbr\u003e\nab203359\u003cbr\u003e\n) is available to use as an alternative to the 96-well microplate provided with SimpleStep ELISA\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Leukocyte-Associated Immunoglobulin-like Receptor 2 (LAIR2) also known as CD306 is a soluble protein with a mass of approximately 15.2 kDa. It can be found in serum where immune system regulation occurs. Structurally LAIR2 shares similarities with LAIR1 a membrane-bound protein although LAIR2 lacks a transmembrane domain. It acts by sequestering ligands that would interact with LAIR1 thereby modulating the immune system response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLAIR2 regulates immune cell function by inhibiting collagen-induced signaling that typically activates immune responses. LAIR2 functions independently without forming a complex with other cell surface receptors or signaling molecules. By binding to collagens this protein limits unnecessary immune activation acting as a checkpoint in immune regulation and maintaining tolerance.\u003cbr\u003e\nPathways\u003cbr\u003e\nMultiple immune regulatory pathways involve LAIR2 including the collagen signaling pathway that modulates immune cell activity. LAIR2 is related to LAIR1 since they both respond to collagen interactions in the immune system. Disruption in these pathways may affect immune homeostasis linking LAIR2 directly to collagen-mediated modulation.\u003cbr\u003e\nDisturbances in LAIR2 expression have links with autoimmune disorders and chronic inflammatory conditions. The protein is of particular interest in studies on systemic lupus erythematosus where altered LAIR2 levels can influence disease progression. Additionally LAIR2 connections with LAIR1 suggest potential implications in fibrotic diseases identifying it as a therapeutic target for modulating immune responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843635859625,"sku":"ab316251","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab316251","provider":"Iright","version":"1.0","type":"link"}