{"product_id":"abcam-ab316371","title":"Abcam, ab316371, Anti-Plakophilin 2\/PKP2 antibody [8H6] - BSA and Azide free","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal Plakophilin 2\/PKP2 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PKP2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:8H6,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PKP2.Q99959\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1 month, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPlakophilin 2 also known as PKP2 is a protein integral to the function of cell junctions specifically within desmosomes. It is one of the plakophilins a subgroup of the armadillo family proteins. The protein has an approximate molecular weight of 97 kDa. PKP2 is extensively expressed in tissues where cells require strong mechanical adhesion such as cardiac and epidermal tissues. It plays an essential role by anchoring intermediate filaments contributing to structural integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPKP2 participates in forming and maintaining stable desmosomal connections in cells. It operates as part of the desmosome complex binding to cadherins and linking them to cytoskeletal filaments. This role is important for maintaining cell-cell adhesion during tissue stress particularly in tissues subject to mechanical stress such as the heart. Its interaction with cadherins and intermediate filaments highlights its role in managing cellular integrity and communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nPKP2 is fundamentally involved in cell signaling and junction-related pathways. It forms part of the desmosomal complex pathway which ensures robust cell adhesion and signaling integrity. PKP2 interacts with other proteins in the pathway such as desmoplakin and plakoglobin aiding mechanical stability and signal transduction necessary for tissue integrity and repair.\u003cbr\u003e\nPKP2 mutations are closely associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) a disease impacting cardiac function. The disorder links PKP2 to desmosomal dysfunction affecting heart muscle integrity and resulting in arrhythmias. Furthermore in the context of skin disorders PKP2 interactions with other desmosomal proteins like desmoglein might influence conditions involving epidermal fragility or blistering.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854518276265,"sku":"ab316371","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab316371","provider":"Iright","version":"1.0","type":"link"}