{"product_id":"abcam-ab317132","title":"Abcam, ab317132, Anti-OAT antibody [HL2088]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal ornithine aminotransferase antibody. Suitable for IHC-P, ICC\/IF, WB and reacts with Mouse, Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human OAT.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL2088,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human OAT.P04181\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOrnithine aminotransferase also known as ornithine transaminase is an enzyme that facilitates the conversion of ornithine and α-ketoglutarate to glutamate semialdehyde and glutamate. This enzyme weighs around 49 kDa. It shows expression mainly in the liver kidney small intestine and retina. The enzyme works inside cellular mitochondria and assists by catalyzing amino group transfer reactions. It is one member of the transaminase family.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme plays a role in the urea cycle and amino acid metabolism. It helps in the conversion of excess nitrogen into less toxic forms that the body can excrete. As a part of an important metabolic network it influences the synthesis and degradation of important biological molecules. It operates independently and does not form known protein complexes for its function.\u003cbr\u003e\nPathways\u003cbr\u003e\nOrnithine aminotransferase is important in the ornithine and glutamate metabolism pathways. Within the urea cycle it cooperates with enzymes such as arginase and carbamoyl phosphate synthetase to regulate nitrogen balance in cells. Additionally it engages in the proline-glutamate pathway which involves proteins like proline dehydrogenase analzying the reversible conversion between proline and glutamate.\u003cbr\u003e\nOrnithine aminotransferase associates with gyrate atrophy a rare genetic condition that affects the eye and leads to vision loss. Deficiencies in this enzyme can result in abnormal accumulations of ornithine in the blood. Some connections also exist with hyperammonemia where impaired nitrogen excretion causes elevated ammonia levels. In these conditions the enzyme's defective activity links to mutations or irregular interactions with proteins like glutamate dehydrogenase affecting metabolic balance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850343665833,"sku":"ab317132","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab317132","provider":"Iright","version":"1.0","type":"link"}